Twenty-four hours in the tentative relationship of two young San Franciscans also dealing with the conundrum of being a minority in a rapidly gentrifying city.

Three time periods - young adolescence, mid-teen and young adult - in the life of black-American Chiron is presented. When a child, Chiron lives with his single, crack addict mother Paula in a crime ridden neighborhood in Miami. Chiron is a shy, withdrawn child largely due to his small size and being neglected by his mother, who is more concerned about getting her fixes and satisfying her carnal needs than taking care of him. Because of these issues, Chiron is bullied, the slurs hurled at him which he doesn't understand beyond knowing that they are meant to be hurtful. Besides his same aged Cuban-American friend Kevin, Chiron is given what little guidance he has in life from a neighborhood drug dealer named Juan, who can see that he is neglected, and Juan's caring girlfriend Teresa, whose home acts as a sanctuary away from the bullies and away from Paula's abuse. With this childhood as a foundation, Chiron may have a predetermined path in life, one that will only be magnified in terms of its problems when he reaches his difficult teen years when peer pressure affects what he and many of his peers do, unless he follows Juan's advice of truly making his own decisions for himself.

African-American teen sweethearts Fonny and Tish are ripped apart when Fonny is wrongly arrested for the rape of a Puerto Rican woman because of the machinations of a racist cop. While seeking justice for Fonny, a pregnant Tish relies on her Harlem community, including her sister, mother Sharon and future mother-in-law.