Newly married couple Marcus and Emily invite their uninhibited besties Ron and Kyla to join them for a vacation when Marcus lands an all-expenses-paid trip to a Caribbean resort. When Kyla’s incarcerated father Reese is released and shows up at the resort unannounced, things get out of control, upending Marcus’ best laid plans and turning the vacation friends’ perfect trip into total chaos.

In this raw and raunchy comedy, straight-laced Marcus and Emily (Lil Rel Howery, Yvonne Orji) are befriended by wild, thrill-seeking partiers Ron and Kyla (John Cena, Meredith Hagner) at a resort in Mexico. Living in the moment, the usually level-headed couple lets loose to enjoy a week of uninhibited fun and debauchery with their new "vacation friends." Months after their walk on the wild side, Marcus and Emily are horrified when Ron and Kyla show up uninvited at their wedding, creating chaos and proving that what happens on vacation, doesn't necessarily stay on vacation.