It's been 20 years since the Sheriff's Department made the gruesome discovery in the basement of the Brookhurst Sanitarium. Unspeakable crimes of freakish experiments performed on female patients at the hands of the sick and demented monster, Dr. Graves. Kari, the lead singer of the all girl punk band The Lolita Dolls has been obsessed with the story about his victims since childhood. After receiving a mysterious e-mail, Kari befriends a 'Fan' online who invites the Band to the Sanitarium to film a video for a song off of their new CD, Fallen Angels. With the help of a Van and their friends Lenny and Steve, the Girls set out on a punk rock road trip of a lifetime, only to discover that the legacy of terror hidden behind the walls of the Brookhurst Sanitarium is far from over.

When Eddie and his friends decide to take their cameras into the woods to debunk the legend of Blood Moon River, they soon realize that they may have bitten off more than they can chew. After searching for two friends that failed to meet them at the campground, their situation goes from bad to worse. A confrontation with a family of psychotic rednecks the next day convinces everyone that it might be a good idea to leave. But after getting a glimpse of something stalking them in the woods...Eddie and his friends realize that the legend of Blood Moon River may be all too real.