After her mother's mysterious death, Nica begins to suspect that the talking, red-haired doll her visiting niece has been playing with may be the key to recent bloodshed and chaos.

Chucky and Tiffany are resurrected by their innocent gender-confused daughter, Glenda, and hit Hollywood, where a movie depicting the killer dolls' murder spree is underway.

After accused of murdering her family, Nica is taken to an asylum and thinks that she's the cause of the deaths of her family. However, when grisly deaths start to occur, she then realizes that Chucky, her illusion might not be make believe. She also finds out that the doll is slowly starting to possess anyone or anything to join a huge cult to kill off Chucky's victims, but things don't go to well in the asylum, including for Chucky's long lost friend, Andy, who tries to stop the cult from getting bigger while also trying to get past Chucky's wife, "Tiffany."