Zach talks Ben into taking off time to go on an adventure of a lifetime. Our two fiends head out on the river, along with an uptight Brit to find Ben's long lost love.

Dr. Ben Cahill, a fine city doctor, gets so stressed by marital problems and alcohol that he freezes up under pressure in the emergency room. To get his act back together, he decides to unwind a few months in the house he and his ex bought on Orr island, an insignificant (former) fishermen place off the coast of Maine. He almost immediately becomes the butt of spite from a gang of local nobodies. After the doctor started examining, at the request of the reasonable sheriff Hobbs who leans to his side, some animal and human corpses with strange internal as well as external injuries, one of the brutes, not so handy handyman Jack Wald, has a fatal nocturnal accident crashing into Dr. Cahill's car. The doc observes one of the red cockroaches which recently infest the island has pincers, most unusual, reads up and contacts the university entomology department, where this African species isn't too well-known either. Jack's even dumber brother Eamon Wald uses violence which ends up causing the sheriff's death, so the doc has no other help then the enterprising local store clerk Nell Bartle, who takes a liking to the only educated men around, to continue investigating fighting off Eamon's gang and as they find out how bad the danger is, try to evacuate...

After a long absence, Chris McCormick returns to his quiet hometown of Prosperity, Arizona, to reopen his late father's mines. However, a chemical spill and lethal toxic waste have created an unstoppable army of giant spiders who prey on the unsuspecting locals, turning Prosperity into an endless buffet. Now, it's up to Chris; Sheriff Sam Parker; her son Mike; Sam's plucky daughter, Ashley; the conspiracy theorist, Harlan, and a handful of survivors to stop the hairy menace, and save the town. But, who can stand in the way of the disgusting eight-legged freaks?

While illegally selling one canister of Trioxyin-5, Charlie Garrison is murdered by a zombie. His nephew Julian Garrison finds two canisters hidden in the attic of his house with his girlfriend Jenny and they ask their friend Cody to analyze and research the chemical product. Cody finds that the composition of the product is very similar to ecstasy and he processes the chemical, making a large quantity of a drug that he called "Z" to make money. Using the services of the local drug dealer, they sell "Z" in the college campus. In the Halloween, the DJ and Jenny's brother Jeremy organizes a rave party. Meanwhile, Julian, Jenny and Cody disclose that the drug transform the users in zombies, and with the support of two weird agents, they try to stop the distribution of "Z".

The scientist of the powerful and evil corporation Hybra-Tech Charles goes to Chernobyl to buy some gallons of toxic waste to perform experiments with zombies. When a teenager has an accident with his motorcycle and vanishes, his teenager's friends, leaded by Charles' nephew, find that he was moved to Hybra-Tech. They break in the facility trying to find their friend and accidentally release a group of zombies starving for brains.