Five close friends, all of them married, share a loft to meet their mistresses. One day they find the body of a young woman in the loft. Since there are only five keys to the loft, the five men begin to suspect each other of murder.

Vincke and Verstuyft are one of the best detective teams of the Antwerp police force. When they are confronted with the disappearance of a top official and the murder of two prostitutes, the trail leads to the almost retired assassin Angelo Ledda. Since Ledda starts showing symptoms of Alzheimer's, it's getting more and more difficult to complete his contracts. When he has to murder a 12-year old call-girl, he refuses and becomes a target himself. While Vincke and Verstuyft are chasing him and counting the corpses, Ledda is taking care of his employers.

The architect Vincent Stevens; the psychiatrist Chris Vanowen; the real estate agents Luke Seacord and Marty Landry; and Chris' half-brother Philip Trauner are married and best friends. Vincent has designed a brand new building and proposes that he and his friends share one of the wonderful penthouse lofts. This would allow them to hook up with other women without worrying about hotel charges showing up on their credit cards. When they discover the body of a beautiful woman cuffed on the bed in the loft, they argue over whom is responsible and secrets are disclosed affecting their friendship.