Former special operative MacGruber is called back into action to take down his arch-enemy, Dieter Von Cunth, who's in possession of a nuclear warhead and bent on destroying Washington, D.C.

When his new album fails to sell records, pop and rap superstar conner4real (Andy Samberg) goes into a major tailspin and watches his celebrity high life begin to collapse. He'll try anything to bounce back, anything except reuniting with his old rap group The Style Boyz.