An acclaimed writer, his ex-wife, and their teenaged children come to terms with the complexities of love in all its forms over the course of one tumultuous year.

Hazel and Augustus are two teenagers who share an acerbic wit, a disdain for the conventional, and a love that sweeps them on a journey. Their relationship is all the more miraculous, given that Hazel's other constant companion is an oxygen tank, Gus jokes about his prosthetic leg, and they meet and fall in love at a cancer support group.

After a near-death experience during a strange tornado, Danielle Moonstar awakens in an abandoned research facility run by the mysterious Dr Cecilia Reyes. There, Dr Reyes introduces Dani to four other equally uncommon teenagers: Illyana Rasputin, Rahne Sinclair, Sam Guthrie, and Roberto da Costa, who wants to keep them safe and sound until they learn how to be in full control of their extraordinary abilities. However, even though the exceptional team of traumatised inmates believes that they're being treated and cared for, before long, they all start to experience horrifying hallucinations. But, this institution was supposed to be a safe place. Are they patients or prisoners?