When the true love between two young lovers is threatened by their families violent feud, their only chance at peace leads them to summoning the monstrous pumpkin head, who brings even greater horrors.

One morning, the cops find eight dead bodies, gunshot victims, near a farmhouse. They also find a wounded man who tells the story of what happened. He is Alan White (Sir John Hurt), the father of a young woman awaiting a heart transplant. The night before, his wounded son Danny (Nick Moran) has come to him with a tale of a kidnapping gone wrong. Danny, whom Alan hasn't seen for eight years, offers a deal. If Alan will pose as a kidnapping victim, which will lead to his death, Danny will donate his heart for his sister's transplant. If Alan refuses, then Danny and his friends, the "new blood" hired to help with the kidnapping, will die. What will Alan do, and what's really going on here?

At Guesta Verde University, the deranged Professor Curien is trying to bring back the dead, killing students for the experiment. There is an outbreak of zombies at the campus, and the government sends an NSA medical research team, formed by Dr. Alexandra Morgan, a.k.a. Nightingale and lieutenant Ellis, with a special force led by lieutenant Dalton, to try to get the zero sample from the first-generation zombie. The team has a very short time to accomplish their mission and leave the place before missiles are sent to destroy the area. However, the place is crowded with hyper sapiens and the group has to fight to survive.

The school teacher Amy has been proposed by her boyfriend Nick early in the morning and she promises her answer later in the afternoon. After her class, while coming back home, Nick has a car accident in a crossroad with a truck driven by Lucas Dylan. He breaks his leg and an ambulance takes him to the hospital. Amy has a phobia about hospitals, but she gets a taxi and goes to the nearest hospital. However, Nick is not there, and she meets Lucas, who is also looking for his sister that has disappeared in the same weird circumstance. They decide to team up and search together where the victims might have been interned, while Amy experiences the most bizarre and scary situations.

A group of young scientists are working on a secret project that may allow them to travel ahead in time. They test it by sending one of their own ahead one hour. He returns pleading with them to shut it down, explaining that within that hour, they will all die.