Four friends decide to take a dream weekend away from work to a local resort island. It soon turns to terror as the local sharks are turning into zombie sharks which also comes to infect people. They four race to find a cure at a local research station that they find is responsible for the infection spreading, but now it is tragedy that hits the group one by one!

Somehow, schools of dangerous sharks have infiltrated the Ozarks lake system, and before long, they become accustomed to living in their new habitat. As siblings, Harrison and Molly, reluctantly join their parents on a trip to the picturesque Ozarks, people get chomped, and the happy holidaymakers find themselves caught in the chaos. Now, as the underwater predators take a liking to the juicy human flesh, no one is safe in the upcoming fireworks festival. But, what has triggered the sharks' aggressive behaviour? Can the remaining survivors rid the lake of the Ozark Sharks?

Right under everyone's noses, a school of aggressive sharks finds its way to the broad Mississippi River, and before long, they attack a slow riverboat, snapping off the unsuspecting tourists' heads. However, with the famous annual fish rodeo just around the corner, the local authorities are not willing to let a few rogue sharks get in the way of having fun, and of course, making a few extra bucks, refusing to understand that, now that the underwater invaders have tasted the succulent human flesh, they'll stop at nothing to get more. Now, it's up to an old familiar face, along with a team of locals, to lend a helping hand, and try to fend off the blood-thirsty aquatic assailants before they all become shark bait. But, can they stop the ferocious Mississippi River Sharks?

Cody is an aspiring comic book artist who happens to be gifted a pen which changes reality, as he first draws Santa Jaws making it come to life as Cody's family and friends are picked off . First no one believes him but soon his remaining family and friends find out it's true and race to battle for survival! Who will win?!