An emotionally fragile woman recently released from a mental hospital for self mutilation goes to school to gain secretarial skills to gain employment. She has an alcoholic father and a co-dependent mother who are clueless as to who she really is which a tormented soul who really wants to find something with which she can find success. She is a great secretary and finds a job with a unique, old fashioned, but off center in charge boss with a somewhat sadistic sexual proclivity. She grows and evolves and so does he.

In 1958, in New York City, the upper class Diane Arbus is a frustrated and lonely woman with a conventional marriage with two daughters. Her husband is a photographer sponsored by the wealthy parents of Diane, and she works as his assistant. When Lionel Sweeney, a mysterious man with hypertrichosis (a.k.a. werewolf syndrome, a disease that causes excessive body hair), comes to live in the apartment in the upper floor, Diane feels a great attraction for him and is introduced to the world of freaks and marginalized people, falling in love with Lionel.

Without even knowing it, Renee, a divorced single mother, and her rebellious teen son, Evan, are being under surveillance in their own home. But who is the one behind the hidden cameras, collecting all this information about this unaware family? Before long, an odd car breakdown will set the stage for Renee's violent abduction, where a group of anything but good Samaritans will take her to a state-of-the-art hidden laboratory to conduct a string of horrifying psychosomatic experiments on her. What are the intentions of Renee's unfeeling snatchers?