A young boy has lost his mother and is losing touch with his father and the world around him. Then he meets Hesher who manages to make his life even more chaotic.

Convinced that his buddy Nardo (Thomas Middleditch) is making the mistake of a lifetime by marrying Tracy (Shannon Woodward), Jason (T.J. Miller) puts a dramatic end to their wedding. When the furious bride decides to take her Baja honeymoon solo, Nardo follows her-where the lovesick groom is carjacked and left stranded, naked and penniless in a remote part of the Mexican desert. Helpless, Nardo sends out an SOS to Jason and their pal Evan (Adam Pally), an up-and-coming ad exec slated for an important business meeting the next morning. During their ridiculous attempt to rescue Nardo, the trio embarks on a series of increasingly outrageous misadventures involving con artists, drug smugglers and even the Federales.