Wendy (Marla Sokoloff) is left a struggling winery in her father's will. While learning to manage it, she must contend with a cunning competitor and her feelings for his son.

In East Mission, Oregon, the Hit Point reporter Chase Carter and the camerawoman Jordan are covering stories from the people in quarantine of a zombie outbreak. The FEZA is using the vaccine Zombrex to inoculate the victims and Chase tries to interview Crystal LaRourke that is on the location. Out of the blue, the patients turn into zombies and Jordan flees with the Hit Point car, leaving Chase behind. He follows Crystal chased by zombies and she stumbles upon Maggie, a woman in shock that has just lost her daughter. They seek shelter in a loan store while Jordan arrives in the border but is sent to quarantine. While the military under the command of General Lyons want to bomb the city since Zombrex is ineffective, Chase, Crystal and Maggie fight to reach the border. Chase discovers a secret about Crystal while Jordan discloses the real intention of General Lyons.

Investigative reporter Chase Carter attempts to stop a secret government conspiracy that threatens the lives of millions of innocent people in a quarantined city during a zombie outbreak. A sequel to the 2015 horror film, Dead Rising (2015).