Kansas City waitress, Betty (Renée Zellweger), with dreams of becoming a nurse, becomes delusional after seeing her no-good car salesman husband murdered. Becoming delusional from shock, she becomes convinced that she is the former fiancée of her soap opera idol. What she also believes is that the soap opera is real and goes to Los Angeles, California to find the hospital where he works as a cardiologist. Meanwhile, her husband's murderers are searching for the drugs stolen by her husband and, as luck would have it, they are stored in the trunk of the car in which she drove off. Charlie (Morgan Freeman), an aging hitman planning his retirement after this job, also becomes delusional about the woman he is tracking.

Conquering ninety percent of the known world by the age of twenty-five, Alexander the Great (Colin Farrell) led his armies through twenty-two thousand miles of sieges and conquests in just eight years. Coming out of tiny Macedonia, Alexander led his armies against the mighty Persian Empire, drove west to Egypt, and finally made his way east to India. This movie concentrated on those eight years of battles, as well as his relationship with his boyhood friend and battle mate, Hephaistion (Jared Leto). Alexander died young, of illness, at the age of thirty-two. Alexander's conquests paved the way for the spread of Greek culture (facilitating the spread of Christianity centuries later), and removed many of the obstacles that might have prevented the expansion of the Roman Empire. In other words, the world we know today might never have been if not for Alexander's bloody, yet unifying, conquest.