Numerous New York City dwellers come to the exclusive club Shortbus to work out problems in their sexual relationships. Rob and Sophia are a happily married couple, except for the fact that she has never experienced sexual climax. This irony follows her to work because she is a couples counselor who frequently has to deal with the sexual issues other couples have. Two of her patients are Jamie and James, a gay couple who have been monogamous for five years and counting. James wants to bring other men in to the relationship, and his own history with depression may hint at an ulterior motive. Ceth (pronounced Seth) may be the perfect addition to their family, but Caleb, a voyeur from across the street, may have his own ideas about that. Sophia visits Severin, a dominatrix with secrets of her own to reveal.

A married police captain arrives at a lake to watch the best meteor shower of the year. At a crossroads in his life, Adam gets an unexpected visit from an eccentric, single nurse. As the night progresses and the conversation gets deeper, Adam and Nicole realize the stars aren't the only things falling.