In a blackly satirical near future, a thriving industry sells celebrity illnesses to their obsessed fans. Employee Syd March's attempts to exploit the system backfire when they involve him in a potentially deadly mystery.

After a robbery gone wrong, Camilla, a veteran paramedic, and her partner Gerry are hijacked and forced to tend to the gunman's badly wounded brother. Held at gunpoint in the back of the rig, Camilla must perform dangerous medical procedures in order to try and save the young man's life, while Gerry drives around the city evading the police. But even if she is successful, can she trust the criminals to honor their word and let them go? Camilla realizes she may have to sacrifice the life she is trying to save in order to save herself and her partner.

Charles has purchased a vintage RV with the hopes of taking his family on a road trip to reconcile with his two sons, a promise he made to his wife before she recently passed. His oldest son, Steve, his wife Jennifer (Denise Richards), their daughter and family dog, are excited for the excursion, however, his youngest son Jay is less than enthusiastic. Along the way, the family picks up Samantha (Mischa Barton) and her brother, broken down on the side of the highway. Before they get them to a service station in the next town, however, Charles insists on taking a detour into the desert to visit a landmark and they soon get lost. Now stranded in the desert, the unsuspecting group is blindsided by the terrible secrets they discover within the walls of the RV and find themselves in the fight of their lives.

The crew of a spaceship headed to Mars discovers an accidental stowaway shortly after takeoff. Too far from Earth to turn back and with resources quickly dwindling, the ship's medical researcher emerges as the only dissenting voice against the group consensus that has already decided in favor of a grim outcome.