Three stories about the world of opioids collide: a drug trafficker arranges a multi-cartel Fentanyl smuggling operation between Canada and the U.S., an architect recovering from an oxycodone addiction tracks down the truth behind her son's involvement with narcotics, and a university professor battles unexpected revelations about his research employer, a drug company with deep government influence bringing a new "non-addictive" painkiller to market.

In the shadow of the Cold War a letter from Oleg Penkovsky (Merab Ninidze) an agency of the Soviet Union received by MI6 stating the concern of Penkovsky about world safety and his anxiety about a nuclear war, So Emily Donovan (Rachel Brosnahan) a CIA Agent reached out to MI6 Agent Dickie Franks (Angus Wright) , who recruited British salesman Greville Wynne (Benedict Cumberbatch) to be their spy.