Athena-1, a space station owned by gene manipulation company Energyne, is destroyed after a laboratory rat mutates and wreaks havoc. Dr. Kerry Atkins, the lone surviving crew member, is ordered by CEO Claire Wyden to retrieve research canisters containing a pathogen. Atkins is able to flee in the escape pod when the station implodes, but due to damage from the rat it disintegrates upon re-entry, killing her. The falling pieces leave a trail of debris across the United States, including the Everglades in Florida, where a canister is consumed by an American crocodile, and a forest in Wyoming, where a gray wolf is exposed to the pathogen. Primatologist Davis Okoye, a former US Army Special Forces soldier and member of an anti-poaching unit, works at the San Diego Wildlife Sanctuary. He has befriended a rare albino western lowland gorilla named George, having saved him from poachers, and communicates with George using sign language and hand gestures. At night, one of the canisters crash-lands in George's habitat, and George is exposed to the pathogen..

The new story follows the heroic efforts of the crypto-zoological agency Monarch as its members face off against a battery of god sized monsters, including the mighty Godzilla, who collides with Mothra, Rodan, and his ultimate nemesis, the three headed King Ghidorah. When these ancient superspecies, thought to be mere myths, rise again, they all vie for supremacy, leaving humanity's very existence hanging in the balance.

A stranded horticulturist-astronaut struggles for survival after he crash lands on a desolate dwarf planet. When an ethereal visitor arrives, the once-lone traveler discovers the joy in building a new life and realizes the universe has delivered astonishing salvation.