When Patrick Sawyer, a Liberian-American collapses upon arrival at the Murtala Mohammed International airport in Lagos, Nigeria. he is taken to Fiest Consultants Hospital, where he is admitted with fever like symptoms. Against his denial of contact with any Ebola victim in Liberia, the team at First Consultants, led by doctor Stella Ameyo Adadevoh, quickly deduce that there is more to his case than malaria. Suddenly they are in a race against time to to contain a very deadly disease from breaking out and spreading in a mega city with a population of over 20 million people and beginning what could be the deadliest disease outbreak the world has ever known.

Hong Kong 1986: A restaurant employee murders his boss and mutilates his wife, he escapes to South Africa where he rapes a Zulu-girl, who is infected with the ebola virus. In the restaurant where he now works he murders his boss and the bosses wife after raping her. He chops them up and makes them into hamburgers, which he sells in the restaurant, spreading the ebola virus. When the police come on his trail he moves back to Hong Kong and an ebola epidemic starts there.