The screams of the children echo throughout the night as a violent reminder of a demon of the past. La Llorona, a paranormal force has returned and seeks the blood of the innocent, proving that the legend is real. Cassandra, during a jog, survives a near rape. Tiffany, young and homeless, comes to the rescue and soon moves in with her new friend. Strange things begin to happen in the household, leading to a possession and the arrival of Father Gomez. After a long battle of faith and courage, the demon is driven out and Cassandra can rebuild her life with her new child, but the fight is not over. The birth of a child, the happiest moment of a young mother's life becomes terrifying as La Llorona finds a new host, continuing the bloody nightmare.

While vacationing in Mexico, a couple discovers their son's disappearance is tied to a supernatural curse.