To free Baba Yaga and Renfield from the clutches of Monster Hunter Mila Starr, the Wishbone Family once more transforms into a Vampire, Frankenstein's Monster, a Mummy and a Werewolf. Aided and abetted by their three pet bats, our Monster Family zooms around the world again to save their friends, make new monstrous acquaintances and finally come to the realization that 'Nobody's Perfect' - even those with flaws can find happiness.

In a world where giant monsters and humans collide, the monsters are superstar athletes and compete in a popular professional wrestling global sport called Monster Wrestling. A young girl named Winnie seeks to follow in her father's footsteps as a manager by coaching a lovable underdog yet-inexperienced monster named Steve. Winnie plans to turn Steve into a champion so that he can go up against the reigning champion Tentacular.

In a small town in central Oregon, Frank Weaver runs a meth lab out of an abandoned mine. While his young son Aiden waits outside the mine in his truck, Frank and an accomplice are attacked by an unseen creature. Investigating strange noises, Aiden is also attacked by the creature. Frank and Aiden survive their encounter with the creature and return home, where their condition quickly worsens. Frank sets up a locked room and demands that no matter what, Aiden's older brother Lucas keeps them locked inside.