A comedy about a cheating husband (Ray Liotta) and an injured high school football star (Shaun Sipos) who become court ordered roommates. Emotional carnage leads to unlikely alliances, as the two men scramble for a second chance at love and stardom.

Roseanne plays a widowed real-estate agent who lives with her teenage son Johnny Galecki. Mother and son have moved to an upstate California town where high school football reigns supreme. When Galecki joins the junior-varsity team, Roseanne, organizes a "mothers vs. sons" football game.

The lives of ten strangers intersect through a terrifying chain of events as a mutating fungus begins to spread through a small town wiping out everyone that comes into contact with it.