A grief counselor working with a group of plane-crash survivors finds herself at the root of a mystery when her clients begin to disappear.

The spaceship, Starship Avalon, in its 120-year voyage to a distant colony planet known as the "Homestead Colony" and transporting 5,258 people has a malfunction in one of its sleep chambers. As a result one hibernation pod opens prematurely and the one person that awakes, Jim Preston (Chris Pratt) is stranded on the spaceship, still 90 years from his destination.