On the streets of New Orleans, word begins to spread about a mysterious new pill that unlocks superpowers unique to each user. The catch: You don't know what will happen until you take it. While some develop bulletproof skin, invisibility, and super strength, others exhibit a deadlier reaction. But when the pill escalates crime within the city to dangerous levels, a local cop (Joseph Gordon-Levitt) teams with a teenage dealer (Dominique Fishback) and a former soldier fueled by a secret vendetta (Jamie Foxx) to fight power with power and risk taking the pill in order to track down and stop the group responsible for creating it.

Severe, pale-eyed, handsome, Phil Burbank is brutally beguiling. All of Phil's romance, power and fragility is trapped in the past and in the land: He can castrate a bull calf with two swift slashes of his knife; he swims naked in the river, smearing his body with mud. He is a cowboy as raw as his hides. The year is 1925. The Burbank brothers are wealthy ranchers in Montana. At the Red Mill restaurant on their way to market, the brothers meet Rose, the widowed proprietress, and her impressionable son Peter. Phil behaves so cruelly he drives them both to tears, revelling in their hurt and rousing his fellow cowhands to laughter - all except his brother George, who comforts Rose then returns to marry her. As Phil swings between fury and cunning, his taunting of Rose takes an eerie form - he hovers at the edges of her vision, whistling a tune she can no longer play. His mockery of her son is more overt, amplified by the cheering of Phil's cowhand disciples. Then Phil appears to take the boy under his wing. Is this latest gesture a softening that leaves Phil exposed, or a plot twisting further into menace?