Melanie has just gained consciousness to discover that she is being held hostage by the Walker family so they can harvest her special skin in order to create a breakthrough skin care cream, and bloom the business; also she's not alone..

A newly divorced young woman, Jude, finds a mysterious, grotesque looking root on her hike and decides to take it home; as she cares for it, she notices that the root changes its appearance. But the change is far from being physical and she soon finds out that there is something far more sinister at play than it being just a ordinary plant. Plagued by horrid and violent hallucinations, Jude fights for her own survival.

A developer relocates to a remote island with his family, where the cursed land takes over his soul and makes him a killer.

In a small town in central Oregon, Frank Weaver runs a meth lab out of an abandoned mine. While his young son Aiden waits outside the mine in his truck, Frank and an accomplice are attacked by an unseen creature. Investigating strange noises, Aiden is also attacked by the creature. Frank and Aiden survive their encounter with the creature and return home, where their condition quickly worsens. Frank sets up a locked room and demands that no matter what, Aiden's older brother Lucas keeps them locked inside.