The story of the relationship between Karamakate, an Amazonian shaman and last survivor of his people, and two scientists who work together over the course of forty years to search the Amazon for a sacred healing plant.

Cristina, a journalist of Mexican origin, travels to her ancestral home in Veracruz to investigate a story of sorcery and healing. There, she is kidnapped by a group of locals who claim she's the devil incarnated.

A family lives an idyllic existence abroad until a tragic accident takes the life of their young son. The inconsolable mother learns of an ancient ritual that will bring him back to say a final goodbye. She travels to an ancient temple, where a door serves as a mysterious portal between two worlds. But when she disobeys a sacred warning to never open that door, she upsets the balance between life and death.