This time, a new baby is on the way, and it's a girl. Wrapped together with the standard conflict between mother and father, Mikey engages in a bit of sibling rivalry with his new sister.

The Szalinski family is back, this time hilarious disaster strikes when an experiment causes their new toddler son to grow many stories tall.

Irresponsible 20-something Jenny arrives in Chicago to live with her older brother Jeff, a young film-maker living a happy existence with his novelist wife Kelly and their two-year-old son. Jenny's arrival shakes up their quiet domesticity as she and her friend Carson instigate an evolution in Kelly's life and career. Meanwhile, Jenny strikes up a rocky relationship with the family's baby sitter-cum-pot dealer.

After an unexpected death in the family, a mother and son struggle to find spiritual healing at a beachfront summer home.