A young man on a cross-country business trip through the Arizona desert picks up a hitchhiker who happens to be a vampire hunter and thus gets himself embroiled in the vampire hunt. His fate gets even more complicated when the hunter takes along with them a woman who is recently bitten by the vampire leader.

John Henry returns to his hometown in hopes of repairing his relationship with his estranged father, but a local gang is terrorizing the town. John Henry is the only one who can stop them, however he has abandoned both his gun and reputation as a fearless quick-draw killer.

In Bucharest, Allison protects the Prophet Lexicon, a mysterious, self-writing bible whose last chapter on the apocalypse (Revelations) will soon disclose the name of the Antichrist on its last page. Stark, the evil and jealous leader of renegade angels called Thrones, forces Dylan, a hit man, to kill Allison to get the information about the Antichrist, but Dylan mysteriously feels attracted by the woman and protects her from the Thrones, instead. Allison seeks John Reigart for help, but he tells her he is interested in the apocalypse to gather millions of souls to Hell. Alone and betrayed, Allison learns the truth about her origins while protecting the Lexicon from Stark.

When a Priest discovers his wife is deathly ill, he decides to go against his faith and use his knowledge of exorcisms to possess her in order to save her life.

In this dark and unique contemporary reimagining of the Shakespearean classic, the saga of MACBETH is told from the point of view of Missy, our misunderstood Lady MacBeth, and shows how love, passion and ambition should never be underestimated.