The Byrdes and their teenage kids, Charlotte and Jonah, are, for all intents and purposes, an ordinary family with ordinary lives. Except for the job of Marty, a Chicago financial advisor who also serves as the top money launderer for the second largest drug cartel in Mexico. When things go awry, Marty must uproot his family from the skyscrapers of Chicago and relocate to the lazy lake region of the Missouri Ozarks.

Somehow, schools of dangerous sharks have infiltrated the Ozarks lake system, and before long, they become accustomed to living in their new habitat. As siblings, Harrison and Molly, reluctantly join their parents on a trip to the picturesque Ozarks, people get chomped, and the happy holidaymakers find themselves caught in the chaos. Now, as the underwater predators take a liking to the juicy human flesh, no one is safe in the upcoming fireworks festival. But, what has triggered the sharks' aggressive behaviour? Can the remaining survivors rid the lake of the Ozark Sharks?