Three years ago, entomologist Dr. Susan Tyler genetically created an insect to kill cockroaches carrying a virulent disease. Now, the insects are out to destroy their only predator, mankind.

When a cockroach-spread plague threatened to decimate the child population of New York City in the original Mimic, biologist Susan Tyler and her research associates developed a crossbreed species of insect, the "Judas Breed" and introduced them into the environment, where they were to spread a toxin, lethal to the cockroaches. The plan worked until the bugs evolved to mimic their next prey.....humans! Just when they were all thought to be dead, the giant Judas bugs are back, and this time they've mutated to take on human form!

In a decaying neighborhood, asthmatic and allergic amateur photographer Marvin Montrose spends his days and nights confined in his room, snooping on his neighbors in the next building with his camera. When a boy disappears in the spot and then the local drug dealer Desmond, Marvin suspects a mysterious garbage man and his sister Rosy and her friend Carmen investigate. Meanwhile, Marvin witnesses the death of Detective Gary Dumars and a stranger on the street by two mutant Judas Breed insects and discloses that their prime suspect is the CDC Agent Kirchner.

A comedy where our main character learns that imitation may not be the sincerest form of flattery when he is befriended by a younger neighbor on the town's newspaper staff. The Kid, who is married but childless, knows no one in town. The Narrator knows everyone in town. As times goes on, the Narrator begins to wonder about the Kid's Wife and what kind of woman could marry a guy like this. Perhaps she just might be the woman for him.