11-year-old Jake Chambers experiences visions involving a Man in Black who seeks to destroy a Tower and bring ruin to the Universe while a Gunslinger opposes him. However, Jake's mother, stepfather and psychiatrists dismiss these as dreams resulting from the trauma of his father's death the previous year. At his apartment home in New York City, a group of workers from an alleged psychiatric facility offer to rehabilitate Jake; recognizing them from his visions as monsters wearing human skin, he flees from the workers who give chase. Jake tracks down an abandoned house from one of his visions where he discovers a high-tech portal that leads to a post-apocalyptic world called Mid-World..

Sam (Andrew Garfield) is a disenchanted 33-year-old who discovers a mysterious woman, Sarah (Riley Keough), frolicking in his apartment's swimming pool. When she vanishes, Sam embarks on a surreal quest across Los Angeles to decode the secret behind her disappearance, leading him into the murkiest depths of mystery, scandal and conspiracy in the City of Angels.

After her husband dies, Sarah and her daughters Chrissy and Kilee moves to a new city hoping for a new life. Kilee hates the move, feeling that they're running away from her dad's memory. When she's bullied at school and is endlessly fighting with her sister, it feels like the world is against her, until she discovers a doll, riddled with pins, in her backyard shed. She soon comes to believe that the doll holds supernatural powers but when it starts acting on its own, Kilee becomes concerned about what she might have unleashed on the people in her life.

Alma and Charlie cross paths with each other, when Charlie finds the perfect tree for the Maine Governor's Holiday Celebration right in Alma's back yard.

Friends Marshall, Gilbert, and Amy accidentally revive and release a mummy from its sarcophagus in the days leading up to Halloween. At first terrified, they quickly learn that the Mummy who they affectionately name 'Harold' is actually very sweet and in dire need of assistance.