To avenge his father's death, a circus entertainer trained in magic and acrobatics turns thief to take down a corrupt bank in Chicago. Two cops from Mumbai are assigned to the case.

A gang of bikers headed by the cool-headed and arrogant Kabir is on a robbing spree in Mumbai. They rob establishments and then zip away on their superbikes. ACP Jai Dixit is the case in-charge and he recruits a bumbling bike mechanic and racer named Ali to chase the gang on a bike and help Jai nab them. Kabir accepts the challenge, and pulls off another robbery amidst a function. This causes Jai and Ali to call it off. Jai resigns from the police force and Ali goes back to his daily job. Meanwhile Kabir has lost one of his team members and recruits Ali for their final job in Goa. The action shifts from the congested Mumbai traffic to the sunny Goa for the final showdown between cops and robbers.

The world's oldest desert, the Namib - A solitary railway line - A royal family on a royal journey. From the sky - like lightening - A flash - the centuries old royal crown is stolen. Back in action - DHOOM:2 reinvents the action comedy genre and propels it into the 21st century. Ali's (Uday Chopra) dream of becoming a police officer has come true. He is now ACP Jai Dixit's (Abhishek Bachchan) right hand man. Together they are trying to keep a tight leash on the crime in India, little do they know what they are going to be up against. Enter Aryan - Mr.A (Hrithik Roshan) A high tech international thief after pulling off a series of impossible heists all over the world. His next target is Mumbai, India. The case is given to ACP Jai Dixit and Ali helping them put the pieces of the puzzle together is ACP Shonali Bose (Bipasha Basu). For the last two years Shonali has been tracking these amazing thefts and is now an expert on this thief, who no one has seen. Once in Mumbai Mr.A finds his match in Sunehri (Aishwarya Rai). A petty yet clever thief. She makes him an offer he finds very hard to refuse. A partnership Aryan accepts. And so the game begins. The cops, Jai, Shonali and Ali and they are after Aryan and Sunehri - The Robbers. From the desert of Namibia to the backwaters of Goa, the mean streets of Mumbai and the ancient forts of Rajasthan and finally to wild and exotic Rio Brazil. Does ACP Jai Dixit manage to nab Mr.A? Go on. Enjoy the ride!. Once again!!.